Apabetalone Mediated Epigenetic Modulation is Associated with Favorable Kidney Function and Alkaline Phosphatase Profile in Patients with Chronic Kidney Disease

Background/Aims: The association between serum alkaline phosphatase (ALP) with adverse cardiovascular outcomes, in Chronic Kidney Disease (CKD) patients has previously been reported and may be a result of increased vascular calcification and inflammation. Here we report, for the first time, the effe...

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Veröffentlicht in:	Kidney & blood pressure research 2018-01, Vol.43 (2), p.449-457
Hauptverfasser:	Kulikowski, Ewelina, Halliday, Christopher, Johansson, Jan, Sweeney, Mike, Lebioda, Kenneth, Wong, Norman, Haarhaus, Mathias, Brandenburg, Vincent, Beddhu, Srinivasan, Tonelli, Marcello, Zoccali, Carmine, Kalantar-Zadeh, Kamyar
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Calcification Calcification (ectopic) Cardiovascular disease Cardiovascular diseases Chemokines Chronic illnesses Clinical trials Coronary vessels Diabetes eGFR Epidermal growth factor receptors Epigenetic Epigenetics Glomerular filtration rate Hypertension Inflammation Kidney diseases Kidneys Laboratories Medicin och hälsovetenskap Modulation Mortality Original Paper Patients Pharmacology Phosphatase Proteins Randomization Smooth muscle Studies Vascular calcification
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Zusammenfassung:	Background/Aims: The association between serum alkaline phosphatase (ALP) with adverse cardiovascular outcomes, in Chronic Kidney Disease (CKD) patients has previously been reported and may be a result of increased vascular calcification and inflammation. Here we report, for the first time, the effects of pharmacologic epigenetic modulation on levels of ALP and kidney function via a novel oral small molecule BET inhibitor, apabetalone, in CKD patients. Methods: A post-hoc analysis evaluated patients with estimated glomerular filtration rate (eGFR)
ISSN:	1420-4096 1423-0143 1423-0143
DOI:	10.1159/000488257