From bench to bedside: a systematic approach to increased laboratory exosome production

Background: Over the last years, interest for microvesicles and exosomes has significantly increased as they revealed a high therapeutical potential for several clinical conditions, such as haemorrhagic shock, cancer, among others. The bottleneck for preclinical and clinical testing remains the reliable production of exosomes with consistent quality, as existing processes not only are unreliable concerning purity and scaling (