Silyl enol etherification by a Tf2NH/amine co-catalytic system for minimizing hazardous waste generation

Silyl enol etherification by a Tf2NH/amine co-catalytic system for minimizing hazardous waste generation

A practical silyl enol etherification of ketones with allylsilanes catalyzed by a Tf2NH–amine co-catalyst under mild conditions has been developed. The reaction generated only volatile isobutene gas as waste. Moreover, a multi-gram synthesis using a microfluidic system and a domino silyl enol etheri...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Reaction chemistry & engineering 2018-01, Vol.3 (5), p.626-630
Hauptverfasser: Kurahashi, Kei, Yamaoka, Yousuke, Takemoto, Yoshiji, Takasu, Kiyosei
Format: Artikel
Sprache:eng ; jpn
Schlagworte:
Catalysis
Chemical synthesis
Cycloaddition
Hazardous wastes
Ketones
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A practical silyl enol etherification of ketones with allylsilanes catalyzed by a Tf2NH–amine co-catalyst under mild conditions has been developed. The reaction generated only volatile isobutene gas as waste. Moreover, a multi-gram synthesis using a microfluidic system and a domino silyl enol etherification–(2 + 2) cycloaddition reaction were demonstrated.
ISSN:2058-9883
DOI:10.1039/c8re00039e