The Important Role of the Nuclearity, Rigidity, and Solubility of Phosphane Ligands in the Biological Activity of Gold(I) Complexes

Invited for the cover of this issue are the groups of Laura Rodríguez, Alexandra R. Fernandes, João Carlos Lima, Pedro V. Baptista, and Kari Rissanen at the Universitat de Barcelona, Universidade Nova de Lisboa, and University of Jyväskylä. The image depicts the direct effect of the phosphine on the different biological activity of Au(I) complexes. Read the full text of the article at 10.1002/chem.201802547. “The activity of the PNaph3 derivative is outstanding, with great selectivity against A2780 ovarian cells, making it a very interesting candidate for ovarian cancer treatment with very low secondary effects.” Read more about the story behind the cover in the Cover Profile and about the research itself on page 14654 ff. (DOI: 10.1002/chem.201802547).