Manufacture and dissolution studies of lipid spheres: Part I

The kinetic release difference between TIl and T12 could be correlated with the significance of the 0.5 mm fraction in the T12 batch (Figure 4). To confirm these hypotheses and to try to moderate sphere floating, the dissolution study was continued with the flow through cell method. The most important benefit of using flow through cell apparatus for the kinetics of spheres is that it regulates the liquid flow that goes through the sphere samples and a homogeneous contact surface can be evaluated.