Orally disintegrating tablets: the path to improved patient compliance and enhanced life cycle management?

Orally disintegrating tablets: the path to improved patient compliance and enhanced life cycle management?

An ODT can also serve as a preferred delivery system for sparingly soluble compounds or compounds where absorption is solubility-limited (BCS class II). With proper selection of formulation excipients (solubilizers, resins, disintegrants, etc.) and processing technology, any issues relating to wetta...

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Veröffentlicht in:Pharmaceutical technology Europe 2009-05, Vol.21 (5), p.25
Hauptverfasser: Pillai, Raviraj, Bokalial, Ranadeep, Karatgi, Pradeep, Wagh, Sanjay, Gawande, Rahul S
Format: Artikel
Sprache:eng
Schlagworte:
Bioequivalence
Clinical trials
Costs
Drug dosages
Generic products
Manufacturing
Mouth
Patients
Pharmaceutical industry
Product life cycle
Product lifecycle management
Resins
Technology
Tongue
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Zusammenfassung:An ODT can also serve as a preferred delivery system for sparingly soluble compounds or compounds where absorption is solubility-limited (BCS class II). With proper selection of formulation excipients (solubilizers, resins, disintegrants, etc.) and processing technology, any issues relating to wettability, solubility and absorption could be overcome to obtain a product with good organoleptic properties that still meets bioequivalency criteria.
ISSN:1753-7967