Applications of Rotary Fluidized Bed Processing, Part I: Manufacturing Spheres

Applications of Rotary Fluidized Bed Processing, Part I: Manufacturing Spheres

Spheres with a constant amount of active drug. Formulations with classic excipients such as lactose or microcrystalline cellulose were produced with a constant amount of active drug used as a tracer. Temperature and rotor speed were kept constant (see Table I). Table II summarizes the production of...

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Veröffentlicht in:Pharmaceutical technology Europe 2001-09, Vol.13 (9), p.22
Hauptverfasser: Gauthier, Pascale, Aiache, Jean-Marc
Format: Artikel
Sprache:eng
Schlagworte:
Cellulose
Drug dosages
Ingredients
Lactose
Manufacturing
Pharmaceuticals
Physical properties
Series & special reports
Spheres
Studies
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Zusammenfassung:Spheres with a constant amount of active drug. Formulations with classic excipients such as lactose or microcrystalline cellulose were produced with a constant amount of active drug used as a tracer. Temperature and rotor speed were kept constant (see Table I). Table II summarizes the production of spheres containing 10% theophylline.The microcrystalline celluloses used, particularly Avicel PH 101, produced regular spheres with good sphericity.
ISSN:1753-7967