An association study ofFOXO3variant and longevity

Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecu-lar, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship be-tween environment factors, oxidative stress status, DNA integrity level, and the association ofFOXO3(rs2802292),SOD2(rs4880),APOE(rs429358 and rs7412), andSIRT1(rs2273773) polymorphisms with longevity in oldest-oldindividuals from southeastern Brazil. We found an association between theFOXO3GG genotype and gender. Whilelifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidativestress were not related to lifespan. We found that long-lived individuals withFOXO3GT genotype had low levels oftriglycerides. This study is the first to demonstrate thatFOXO3could be a candidate gene for longevity in the Brazil-ian population. These results are important in terms of provisions of health care for age-related diseases and life-span, and provide insight for further research on epigenetic, gene regulation, and expression in oldest-oldindividuals.