Experimental and computational methods for understanding pharmaceutical flows, Part II: large-scale production equipment

Experimental and computational methods for understanding pharmaceutical flows, Part II: large-scale production equipment

Having a validated model for non-- Newtonian fluids is extremely valuable for predicting the behaviour of these fluids in larger and/or more complex equipment that cannot be easily validated. Because cavern sizes and non-Newtonian behaviour can change on scale-up in manners that cannot be simply cor...

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Veröffentlicht in:Pharmaceutical technology Europe 2003-04, Vol.15 (4), p.31
Hauptverfasser: Kukura, Joseph, Arratia, Paulo E, Szalai, Edit S, Johnson, Keith E, Muzzio, Fernando J
Format: Artikel
Sprache:eng
Schlagworte:
Drugs
Equipment and supplies
Evaluation
Experiments
Fluid dynamics
Laboratories
Non-Newtonian fluids
Pharmaceutical industry
Pharmaceuticals
Production functions
Production management
Reynolds number
Series & special reports
Ultraviolet radiation
Velocity
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Zusammenfassung:Having a validated model for non-- Newtonian fluids is extremely valuable for predicting the behaviour of these fluids in larger and/or more complex equipment that cannot be easily validated. Because cavern sizes and non-Newtonian behaviour can change on scale-up in manners that cannot be simply correlated to dimensionless numbers, the implementation of validated CFD models may prove to be the most effective way to scale-up processes with shear-- thinning fluids.
ISSN:1753-7967