The risk of gastric cancer in patients with glutathione s-transferases (GSTS) gene polymorphisms
Glutathione S-transferases (GSTs) are among the most important enzymes which protect human cells against toxic and genotoxic effect of exogenous and endogenous substances, because of detoxification through catalyzing the reaction of binding glutathione with a great number of pharmacologically active...
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| Veröffentlicht in: | Human & veterinary medicine 2018-09, Vol.10 (3), p.104-110 |
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| creator | Chirila, Daciana N Chirila, Mihaela D Micu, Bogdan V Istoan, Smaranda A Muresan, Mihai S Gligor, Daniel Pop, Tudor R |
| description | Glutathione S-transferases (GSTs) are among the most important enzymes which protect human cells against toxic and genotoxic effect of exogenous and endogenous substances, because of detoxification through catalyzing the reaction of binding glutathione with a great number of pharmacologically active substances. The locations for GST genes are different. The patients with dual null GSTM1+GSTT1 genotype exhibit a whole absence of their enzymes activity; genes changes in other GSTs determine alterations of enzyme activity which may be the trigger to malignant transformation. The present paper searched data dealing with the involvement of some GST polymorphisms in the development of gastric cancer. This relationship in time offered different conclusions, but some polymorphisms of the GSTs supergene family seem to be associated with an increase in the risk of gastric cancer depending on different ethnicities. |
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| ispartof | Human & veterinary medicine, 2018-09, Vol.10 (3), p.104-110 |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Detoxification Enzymatic activity Enzymes Gastric cancer Genes Genetic transformation Genotoxicity Genotype & phenotype Glutathione GSTM1 protein GSTT1 protein Infections Meta-analysis Metabolism Population Systematic review White people |
| title | The risk of gastric cancer in patients with glutathione s-transferases (GSTS) gene polymorphisms |
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