The risk of gastric cancer in patients with glutathione s-transferases (GSTS) gene polymorphisms

Glutathione S-transferases (GSTs) are among the most important enzymes which protect human cells against toxic and genotoxic effect of exogenous and endogenous substances, because of detoxification through catalyzing the reaction of binding glutathione with a great number of pharmacologically active...

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Veröffentlicht in:Human & veterinary medicine 2018-09, Vol.10 (3), p.104-110
Hauptverfasser: Chirila, Daciana N, Chirila, Mihaela D, Micu, Bogdan V, Istoan, Smaranda A, Muresan, Mihai S, Gligor, Daniel, Pop, Tudor R
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Sprache:eng
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Zusammenfassung:Glutathione S-transferases (GSTs) are among the most important enzymes which protect human cells against toxic and genotoxic effect of exogenous and endogenous substances, because of detoxification through catalyzing the reaction of binding glutathione with a great number of pharmacologically active substances. The locations for GST genes are different. The patients with dual null GSTM1+GSTT1 genotype exhibit a whole absence of their enzymes activity; genes changes in other GSTs determine alterations of enzyme activity which may be the trigger to malignant transformation. The present paper searched data dealing with the involvement of some GST polymorphisms in the development of gastric cancer. This relationship in time offered different conclusions, but some polymorphisms of the GSTs supergene family seem to be associated with an increase in the risk of gastric cancer depending on different ethnicities.
ISSN:2066-7655
2066-7663