Instrumental neutron activation analysis, a technique for measurement of Se, Hg, Fe, Zn, K, Mn, Br, and the Hg:Se ratio in brain tissue samples with results from the Memory and Aging Project (MAP)

An INAA method for measurement of Se, Hg, Fe, Cr, Zn, Mn, K, and Br in autopsy cerebellum, anterior putamen, white matter, mid-frontal cortex, and inferior temporal lobe. Se, Hg, Fe, Cr, and Zn were measured autopsy samples collected from participants of the Memory and Aging Project. The first study examined the association between seafood consumption, brain Hg and Se, Apolipoprotein E (APOE-ε4) status, and brain neuropathology. Following the initial study, the samples were archived. A subsequent method was developed to measure Mn, K, and Br in the archived brain tissue samples.