Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids
Interleukin (IL)-8, the C-X-C chemokine, is a potent neutrophil chemoattractant that has been implicated in a number of inflammatory airway diseases such as cystic fibrosis. Rodgers et al tested the hypothesis that bradykinin, an inflammatory mediator and chloride secretagogue, would increase IL-8 g...
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Veröffentlicht in: | American journal of physiology. Lung cellular and molecular physiology 2002-09, Vol.27 (3), p.L612-L618 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Interleukin (IL)-8, the C-X-C chemokine, is a potent neutrophil chemoattractant that has been implicated in a number of inflammatory airway diseases such as cystic fibrosis. Rodgers et al tested the hypothesis that bradykinin, an inflammatory mediator and chloride secretagogue, would increase IL-8 generation in airway epithelial cells through autocrine generation of endogenous prostanoids. |
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ISSN: | 1040-0605 1522-1504 |