Leukotoxin, 9,10-epoxy-12-octadecenoate causes edematous lung injury via activation of vascular nitric oxide synthase
The mechanism of leukotoxin, 9,10-epoxy-12-octadecenoate (Lx)-induced lung injury was investigated in blood-free, physiological salt solution-perfused rat lungs under constant flow conditions. Since both nitric oxide synthase inhibitors and superoxide dismutase inhibited the Lx-induced lung injury,...
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| Veröffentlicht in: | American journal of physiology. Lung cellular and molecular physiology 1995-07, Vol.13 (1), p.L65-L70 |
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| container_end_page | L70 |
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| container_issue | 1 |
| container_start_page | L65 |
| container_title | American journal of physiology. Lung cellular and molecular physiology |
| container_volume | 13 |
| creator | ISHIZAKI, T SHIGEMORI, K NAKAI, T MIYABO, S OZAWA, T SHI-WEN CHANG VOELKEL, B. F |
| description | The mechanism of leukotoxin, 9,10-epoxy-12-octadecenoate (Lx)-induced lung injury was investigated in blood-free, physiological salt solution-perfused rat lungs under constant flow conditions. Since both nitric oxide synthase inhibitors and superoxide dismutase inhibited the Lx-induced lung injury, peroxynitrite could be involved in the mechanism whereby Lx causes lung injury. |
| format | Article |
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| identifier | ISSN: 1040-0605 |
| ispartof | American journal of physiology. Lung cellular and molecular physiology, 1995-07, Vol.13 (1), p.L65-L70 |
| issn | 1040-0605 1522-1504 |
| language | eng |
| recordid | cdi_proquest_journals_210939662 |
| source | Alma/SFX Local Collection |
| subjects | Biochemistry Biological and medical sciences Injuries Lungs Medical sciences Pneumology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases |
| title | Leukotoxin, 9,10-epoxy-12-octadecenoate causes edematous lung injury via activation of vascular nitric oxide synthase |
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