Leukotoxin, 9,10-epoxy-12-octadecenoate causes edematous lung injury via activation of vascular nitric oxide synthase

The mechanism of leukotoxin, 9,10-epoxy-12-octadecenoate (Lx)-induced lung injury was investigated in blood-free, physiological salt solution-perfused rat lungs under constant flow conditions. Since both nitric oxide synthase inhibitors and superoxide dismutase inhibited the Lx-induced lung injury,...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 1995-07, Vol.13 (1), p.L65-L70
Hauptverfasser:	ISHIZAKI, T, SHIGEMORI, K, NAKAI, T, MIYABO, S, OZAWA, T, SHI-WEN CHANG, VOELKEL, B. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and medical sciences Injuries Lungs Medical sciences Pneumology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases
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Zusammenfassung:	The mechanism of leukotoxin, 9,10-epoxy-12-octadecenoate (Lx)-induced lung injury was investigated in blood-free, physiological salt solution-perfused rat lungs under constant flow conditions. Since both nitric oxide synthase inhibitors and superoxide dismutase inhibited the Lx-induced lung injury, peroxynitrite could be involved in the mechanism whereby Lx causes lung injury.
ISSN:	1040-0605 1522-1504