Recombinant GM-CSF reduces lung injury and mortality during neutropenic Candida sepsis

Recombinant GM-CSF reduces lung injury and mortality during neutropenic Candida sepsis

A comprehensive immunophysiological model of subacute hematogenous infection with 10 million yeast-phase Candida albicans in chronically instrumented antibiotic-treated rats was used to examine the impact of murine recombinant murine granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF...

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Veröffentlicht in:American journal of physiology. Lung cellular and molecular physiology 1994-05, Vol.10 (5), p.L561-L568
Hauptverfasser: LECHNER, A. J, LAMPRECH, K. E, POTTHOFF, L. H, TREDWAY, T. L, MATUSCHAK, G. M
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Biochemistry
Biological and medical sciences
Injuries
Lungs
Medical sciences
Mortality
Pharmacology. Drug treatments
Rodents
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Zusammenfassung:A comprehensive immunophysiological model of subacute hematogenous infection with 10 million yeast-phase Candida albicans in chronically instrumented antibiotic-treated rats was used to examine the impact of murine recombinant murine granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF reduces lung injury and mortality.
ISSN:1040-0605
1522-1504