Induction of A- and D-type cyclins and cdc2 kinase activity during recovery from short-term hyperoxic lung injury

The key events of cell cycle control in type II alveolar epithelial cells (AEC) after hypoxic injury were studied: induction of cyclins and cdks in whole lung, in freshly isolated AEC and in primary cultures of AEC isolated from oxygen-exposed and control rat lungs. Cyclins A and D are induced and p...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 1995-04, Vol.12 (4), p.L625-L635
Hauptverfasser:	KIM CHI BUI, BUCKLEY, S, WU, F, UHAL, B, IRAVATI JOSHI, JIAN LIU, MUKARRAM HUSSAIN, IMAD MAKHOUL, WARBURTON, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Biological and medical sciences Cellular biology Fundamental and applied biological sciences. Psychology Lungs Oxygen Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Rodents Vertebrates: respiratory system
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Beschreibung
Zusammenfassung:	The key events of cell cycle control in type II alveolar epithelial cells (AEC) after hypoxic injury were studied: induction of cyclins and cdks in whole lung, in freshly isolated AEC and in primary cultures of AEC isolated from oxygen-exposed and control rat lungs. Cyclins A and D are induced and p34cdc2 are activated in AEC during the process of repair after hyperoxic lung injury.
ISSN:	1040-0605 1522-1504