Endothelin-1 is elevated in monocrotaline pulmonary hypertension

Theses studies document striking pulmonary vasoconstrictor response to nitric oxide synthase (NOS) inhibition in monocrotaline (MCT) pulmonary hypertension in rats. This constriction is caused by elevated endothelin (ET)-1 production acting on ETA receptors.

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Veröffentlicht in:American journal of physiology. Lung cellular and molecular physiology 1999-02, Vol.20 (2), p.L304-L310
Hauptverfasser: FRASCH, H. F, MARSHALL, C, MARSHALL, B. E
Format: Artikel
Sprache:eng
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Zusammenfassung:Theses studies document striking pulmonary vasoconstrictor response to nitric oxide synthase (NOS) inhibition in monocrotaline (MCT) pulmonary hypertension in rats. This constriction is caused by elevated endothelin (ET)-1 production acting on ETA receptors.
ISSN:1040-0605
1522-1504