Delayed rectifier K+ current of dog bronchial myocytes : effect of pollen sensitization and PKC activation

The properties of delayed rectifier K+ current AIK(dr)B of canine airway smooth muscle cells isolated from small bronchi and its modulation by protein kinase C (PKC) were studied by whole cell patch clamp. IK(dr) activated positive to -40 mV, with half-maximal activation at -16 +/-1.2 mV (n = 15) an...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 1998-08, Vol.19 (2), p.L336-L347
Hauptverfasser:	WALDRON, G. J, SIGURDSSON, S. B, AIELLO, E. A, HALAYKO, A. J, STEPHENS, N. L, COLE, W. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell physiology Cells Cellular biology Dogs Fundamental and applied biological sciences. Psychology Membrane and intracellular transports Molecular and cellular biology Pollen Potassium Proteins Respiratory system
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Zusammenfassung:	The properties of delayed rectifier K+ current AIK(dr)B of canine airway smooth muscle cells isolated from small bronchi and its modulation by protein kinase C (PKC) were studied by whole cell patch clamp. IK(dr) activated positive to -40 mV, with half-maximal activation at -16 +/-1.2 mV (n = 15) and average current density of 31 +/-2.6 pA/pF (n = 15) at +30 mV.
ISSN:	1040-0605 1522-1504