Regulation of connective tissue growth factor expression by prostaglandin E2

Transforming growth factor-beta (TGF-beta) stimulates alpha1(I) collagen mRNA synthesis in human lung fibroblasts through a mechanism that is partially sensitive to cycloheximide and that may involve synthesis of connective tissue growth factor (CTGF). Northern blot analyses indicate that TGF-beta s...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 1999-12, Vol.21 (6), p.L1165-L1171
Hauptverfasser:	RICUPERO, D. A, RISHIKOF, D. C, KUANG, P.-P, POLIKS, C. F, GOLDSTEIN, R. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Amino acids Biological and medical sciences Fundamental and applied biological sciences. Psychology Respiratory system Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Tissues Tumors Vertebrates: respiratory system
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Zusammenfassung:	Transforming growth factor-beta (TGF-beta) stimulates alpha1(I) collagen mRNA synthesis in human lung fibroblasts through a mechanism that is partially sensitive to cycloheximide and that may involve synthesis of connective tissue growth factor (CTGF). Northern blot analyses indicate that TGF-beta stimulates time- and dosedependent increases in CTGF mRNA.
ISSN:	1040-0605 1522-1504