CD4+ T cell-dependent airway mucus production occurs in response to IL-5 expression in lung

CD4+ T cell-dependent airway mucus production occurs in response to IL-5 expression in lung

Researchers used a pulmonary interleukin-5 (IL-5) transgenic mouse model in which naive transgenic mice display comparable levels of airway mucus relative to allergen-sensitized and -challenged wild-type mice to demonstrate the potential role of airway IL-5 expression in eliciting mucus production.

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Veröffentlicht in:American journal of physiology. Lung cellular and molecular physiology 2002-05, Vol.26 (5), p.L1066-L1074
Hauptverfasser: JUSTICE, J. Paul, CROSBY, J, BORCHERS, M. T, TOMKINSON, A, LEE, J. J, LEE, N. A
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Body fluids
Chronic obstructive pulmonary disease, asthma
Cytokines
Lungs
Medical sciences
Pneumology
Rodents
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Zusammenfassung:Researchers used a pulmonary interleukin-5 (IL-5) transgenic mouse model in which naive transgenic mice display comparable levels of airway mucus relative to allergen-sensitized and -challenged wild-type mice to demonstrate the potential role of airway IL-5 expression in eliciting mucus production.
ISSN:1040-0605
1522-1504