GM-CSF regulates protein and lipid catabolism by alveolar macrophages

Metabolism of surfactant protein (SP) A and dipalmitoylphosphatidyleholine (DPPC) was assessed in alveolar macrophages isolated from granulocyte-macrophage colony-stimulated factor (GM-CSF) gene-targeted [GM(-/-)] mice, wild-type mice, and GM(-/-) mice expressing GM-CSF under control of the SP-C pro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2001-03, Vol.24 (3), p.L379-L386
Hauptverfasser:	YOSHIDA, Mitsuhiro, IKEGAMI, Machiko, REED, Jacquelyn A, CHRONEOS, Zissis C, WHITSETT, Jeffrey A
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Anatomy & physiology Biological and medical sciences Fundamental and applied biological sciences. Psychology Lipids Lungs Metabolism Proteins Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Vertebrates: respiratory system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Metabolism of surfactant protein (SP) A and dipalmitoylphosphatidyleholine (DPPC) was assessed in alveolar macrophages isolated from granulocyte-macrophage colony-stimulated factor (GM-CSF) gene-targeted [GM(-/-)] mice, wild-type mice, and GM(-/-) mice expressing GM-CSF under control of the SP-C promoter element (SP-C-GM). Although binding and uptake of 125 I-SP-A were significantly increased in alveolar macrophages from GM(-/-) compared with wild type or SP-C-GM mice, catabolism of 125 I-SP-A was markedly decreased in GM(-/-) mice.
ISSN:	1040-0605 1522-1504