Noninvasive detection of endotoxin-induced mucus hypersecretion in rat lung by MRI

Using magnetic resonance imaging, Beckmann et al detected a signal in the lungs of Brown Norway rats after intratracheal administration of endotoxin. The prospect of non-invasively detected a sustained mucus hypersecretory phenotype in the lung brings an important new perspective to models of chroni...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2002-07, Vol.27 (1), p.L22-L30
Hauptverfasser:	BECKMANN, Nicolau, TIGANI, Bruno, SUGAR, Rosemary, JACKSON, Alan D, JONES, Gareth, MAZZONI, Lazzaro, FOZARD, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cells Investigative techniques, diagnostic techniques (general aspects) Lungs Medical sciences NMR Nuclear magnetic resonance Radiodiagnosis. Nmr imagery. Nmr spectrometry Respiratory diseases Respiratory system Rodents
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Beschreibung
Zusammenfassung:	Using magnetic resonance imaging, Beckmann et al detected a signal in the lungs of Brown Norway rats after intratracheal administration of endotoxin. The prospect of non-invasively detected a sustained mucus hypersecretory phenotype in the lung brings an important new perspective to models of chronic obstructive pulmonary diseases in animals.
ISSN:	1040-0605 1522-1504