Phosphocholine reverses inhibition of pulmonary surfactant adsorption caused by C-reactive protein

The effects of human C-reactive protein (CRP) on the adsorption rate of whole porcine lung surfactant were investigated. The potent inhibition of surfactant adsorption by CRP is mainly a result of a specific interaction between CRP and the phosphocholine headgroup of surfactant lipids in the subphas...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 1995-10, Vol.13 (4), p.L492-L497
Hauptverfasser:	MCEACHREN, T. M, KEOUGH, K. M. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Biochemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology Hogs Lungs Proteins Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Vertebrates: respiratory system
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Zusammenfassung:	The effects of human C-reactive protein (CRP) on the adsorption rate of whole porcine lung surfactant were investigated. The potent inhibition of surfactant adsorption by CRP is mainly a result of a specific interaction between CRP and the phosphocholine headgroup of surfactant lipids in the subphase.
ISSN:	1040-0605 1522-1504