Lung uptake of antibodies to endothelial antigens : key determinants of vascular immunotargeting

Lung uptake of antibodies to endothelial antigens : key determinants of vascular immunotargeting

Vascular immunotargeting is a mean for a site-selective delivery of drugs and genes to endothelium. In this study, we compared recognition of pulmonary and systemic vessels in rats by candidate carrier monoclonal antibodies (MAbs) to endothelial antigens platelet endothelial cell adhision molecule (...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of physiology. Lung cellular and molecular physiology 2001-06, Vol.24 (6), p.L1335-L1347
Hauptverfasser: DANILOV, Sergei M, GAVRILYUK, Vitaly D, FRANKE, Folker E, PAULS, Katarina, HARSHAW, David W, MCDONALD, Timothy D, MILETICH, David J, MUZYKANTOV, Vladimir R
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Enzymes
Genes
Immune system
Lungs
Medical sciences
Pharmacology. Drug treatments
Respiratory system
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Vascular immunotargeting is a mean for a site-selective delivery of drugs and genes to endothelium. In this study, we compared recognition of pulmonary and systemic vessels in rats by candidate carrier monoclonal antibodies (MAbs) to endothelial antigens platelet endothelial cell adhision molecule (PECAM)-1 (CD31), intercellular adhesion molecule (ICAM)-1 (CD54), Thy-1.1 (CD90.1), angiotensin-coverting enzyme (ACE; CD143), and OX-43.
ISSN:1040-0605
1522-1504