Cytoskeletal regulation of the L-arginine/NO pathway in pulmonary artery endothelial cells

We investigated possible involvement of the actin cytoskeleton in the regulation of the L-arginine/nitric oxide (NO) pathway in pulmonary artery endothelial cells (PAEC). We exposed cultured PAEC to swinholide A (Swinh), which severs actin microfilaments, or jasplakinolide (Jasp), which stabilizes a...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2001-03, Vol.24 (3), p.L465-L473
Hauptverfasser:	ZHARIKOV, Sergey I, SIGOVA, Alla A, SIFENG CHEN, BUBB, Michael R, BLOCK, Edward R
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Amino acids Anatomy & physiology Biological and medical sciences Blood vessels Cells Fundamental and applied biological sciences. Psychology Lungs Regulation Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Vertebrates: respiratory system
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Zusammenfassung:	We investigated possible involvement of the actin cytoskeleton in the regulation of the L-arginine/nitric oxide (NO) pathway in pulmonary artery endothelial cells (PAEC). We exposed cultured PAEC to swinholide A (Swinh), which severs actin microfilaments, or jasplakinolide (Jasp), which stabilizes actin filaments and promotes actin polymerization, or both.
ISSN:	1040-0605 1522-1504