Target induced reconstruction of DNAzymatic amplifier nanomachines in living cells for concurrent imaging and gene silencing
A novel DNAzymatic amplifier nanomachine that is reconstructed in response to an mRNA input has been developed to enable the functions of concurrent sensitive mRNA imaging and activatable gene therapy in living cells. A novel DNAzymatic amplifier nanomachine that enables the functions of concurrent...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2018, Vol.54 (75), p.1626-1629 |
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| container_end_page | 1629 |
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| container_issue | 75 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 54 |
| creator | Li, Jun-Jie Li, Wan-Ning Du, Wen-Fang Lv, Meng-Mei Wu, Zhen-Kun Jiang, Jian-Hui |
| description | A novel DNAzymatic amplifier nanomachine that is reconstructed in response to an mRNA input has been developed to enable the functions of concurrent sensitive mRNA imaging and activatable gene therapy in living cells.
A novel DNAzymatic amplifier nanomachine that enables the functions of concurrent mRNA imaging and gene silencing in living cells has been reported. |
| doi_str_mv | 10.1039/c8cc05832f |
| format | Article |
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A novel DNAzymatic amplifier nanomachine that enables the functions of concurrent mRNA imaging and gene silencing in living cells has been reported.</description><subject>Amplifiers</subject><subject>Biosensing Techniques - methods</subject><subject>Carbocyanines - chemistry</subject><subject>Cell Line, Tumor</subject><subject>Cells (biology)</subject><subject>DNA, Catalytic - chemistry</subject><subject>DNA, Catalytic - genetics</subject><subject>DNA, Single-Stranded - chemistry</subject><subject>DNA, Single-Stranded - genetics</subject><subject>Early Growth Response Protein 1 - genetics</subject><subject>Early Growth Response Protein 1 - metabolism</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Gene Silencing</subject><subject>Gene therapy</subject><subject>Humans</subject><subject>Microscopy, Confocal</subject><subject>Nanostructures - chemistry</subject><subject>Nucleic Acid Amplification Techniques - instrumentation</subject><subject>Nucleic Acid Hybridization</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Theranostic Nanomedicine - methods</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc9LHTEQx0NR_FUvvSsBL1JYTTbJ2-zxsa21IHqx0NuSnZ28RnaTZ7IrWPzjm9dnFTqXGWY-82WGLyGfOLvgTNSXoAGY0qK0H8gBFwtZKKl_7mxqVReVkGqfHKb0wHJwpffIvmC80pWuD8jLvYkrnKjz_QzY04gQfJriDJMLngZLv9wufz-PZnJAzbgenHUYqTc-jAZ-OY8p79LBPTm_ooDDkKgNkWYVmGNEn6VHs9oMje_pCj3S5Ab0kFsfya41Q8Lj13xEflx9vW-ui5u7b9-b5U0BkompQIO14mUl8oeqkx0HJSvGNRhmregXnVYLBrW2RrPO6EVn-16UQvWAsmMA4oicb3XXMTzOmKZ2dGlzq_EY5tSWrK6lkIzLjJ79hz6EOfp8XVtypjmrS64y9XlLQQwpRbTtOuY343PLWbvxpG100_z15CrDp6-Sczdi_4b-MyEDJ1sgJnibvpsq_gACeZLb</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Li, Jun-Jie</creator><creator>Li, Wan-Ning</creator><creator>Du, Wen-Fang</creator><creator>Lv, Meng-Mei</creator><creator>Wu, Zhen-Kun</creator><creator>Jiang, Jian-Hui</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1594-4023</orcidid></search><sort><creationdate>2018</creationdate><title>Target induced reconstruction of DNAzymatic amplifier nanomachines in living cells for concurrent imaging and gene silencing</title><author>Li, Jun-Jie ; Li, Wan-Ning ; Du, Wen-Fang ; Lv, Meng-Mei ; Wu, Zhen-Kun ; Jiang, Jian-Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-eae95127332f5b4b1c547018ca0ff3d6b8560c98fa80ba86bfdd3235dce4b0cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amplifiers</topic><topic>Biosensing Techniques - methods</topic><topic>Carbocyanines - chemistry</topic><topic>Cell Line, Tumor</topic><topic>Cells (biology)</topic><topic>DNA, Catalytic - chemistry</topic><topic>DNA, Catalytic - genetics</topic><topic>DNA, Single-Stranded - chemistry</topic><topic>DNA, Single-Stranded - genetics</topic><topic>Early Growth Response Protein 1 - genetics</topic><topic>Early Growth Response Protein 1 - metabolism</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Gene Silencing</topic><topic>Gene therapy</topic><topic>Humans</topic><topic>Microscopy, Confocal</topic><topic>Nanostructures - chemistry</topic><topic>Nucleic Acid Amplification Techniques - instrumentation</topic><topic>Nucleic Acid Hybridization</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Theranostic Nanomedicine - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jun-Jie</creatorcontrib><creatorcontrib>Li, Wan-Ning</creatorcontrib><creatorcontrib>Du, Wen-Fang</creatorcontrib><creatorcontrib>Lv, Meng-Mei</creatorcontrib><creatorcontrib>Wu, Zhen-Kun</creatorcontrib><creatorcontrib>Jiang, Jian-Hui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jun-Jie</au><au>Li, Wan-Ning</au><au>Du, Wen-Fang</au><au>Lv, Meng-Mei</au><au>Wu, Zhen-Kun</au><au>Jiang, Jian-Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Target induced reconstruction of DNAzymatic amplifier nanomachines in living cells for concurrent imaging and gene silencing</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2018</date><risdate>2018</risdate><volume>54</volume><issue>75</issue><spage>1626</spage><epage>1629</epage><pages>1626-1629</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>A novel DNAzymatic amplifier nanomachine that is reconstructed in response to an mRNA input has been developed to enable the functions of concurrent sensitive mRNA imaging and activatable gene therapy in living cells.
A novel DNAzymatic amplifier nanomachine that enables the functions of concurrent mRNA imaging and gene silencing in living cells has been reported.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>30178789</pmid><doi>10.1039/c8cc05832f</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-1594-4023</orcidid></addata></record> |
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| ispartof | Chemical communications (Cambridge, England), 2018, Vol.54 (75), p.1626-1629 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amplifiers Biosensing Techniques - methods Carbocyanines - chemistry Cell Line, Tumor Cells (biology) DNA, Catalytic - chemistry DNA, Catalytic - genetics DNA, Single-Stranded - chemistry DNA, Single-Stranded - genetics Early Growth Response Protein 1 - genetics Early Growth Response Protein 1 - metabolism Fluorescent Dyes - chemistry Gene Silencing Gene therapy Humans Microscopy, Confocal Nanostructures - chemistry Nucleic Acid Amplification Techniques - instrumentation Nucleic Acid Hybridization RNA, Messenger - genetics RNA, Messenger - metabolism Theranostic Nanomedicine - methods |
| title | Target induced reconstruction of DNAzymatic amplifier nanomachines in living cells for concurrent imaging and gene silencing |
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