Target induced reconstruction of DNAzymatic amplifier nanomachines in living cells for concurrent imaging and gene silencing

A novel DNAzymatic amplifier nanomachine that is reconstructed in response to an mRNA input has been developed to enable the functions of concurrent sensitive mRNA imaging and activatable gene therapy in living cells. A novel DNAzymatic amplifier nanomachine that enables the functions of concurrent...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2018, Vol.54 (75), p.1626-1629
Hauptverfasser:	Li, Jun-Jie, Li, Wan-Ning, Du, Wen-Fang, Lv, Meng-Mei, Wu, Zhen-Kun, Jiang, Jian-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplifiers Biosensing Techniques - methods Carbocyanines - chemistry Cell Line, Tumor Cells (biology) DNA, Catalytic - chemistry DNA, Catalytic - genetics DNA, Single-Stranded - chemistry DNA, Single-Stranded - genetics Early Growth Response Protein 1 - genetics Early Growth Response Protein 1 - metabolism Fluorescent Dyes - chemistry Gene Silencing Gene therapy Humans Microscopy, Confocal Nanostructures - chemistry Nucleic Acid Amplification Techniques - instrumentation Nucleic Acid Hybridization RNA, Messenger - genetics RNA, Messenger - metabolism Theranostic Nanomedicine - methods
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Beschreibung
Zusammenfassung:	A novel DNAzymatic amplifier nanomachine that is reconstructed in response to an mRNA input has been developed to enable the functions of concurrent sensitive mRNA imaging and activatable gene therapy in living cells. A novel DNAzymatic amplifier nanomachine that enables the functions of concurrent mRNA imaging and gene silencing in living cells has been reported.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c8cc05832f