Effect of Molecular Weight and Degree of Acetylation on Adjuvantive Properties of Chitosan Derivatives

Effect of Molecular Weight and Degree of Acetylation on Adjuvantive Properties of Chitosan Derivatives

The hemostatic and immunostimulating activity and cytotoxicity were determined for a number of chitosans differing in molecular weight (from 3 to 510 kDa) and degree of acetylation (from 1 to 25 mol%) that were used as adjuvants in inactivated poliomyelitic, influenza, and live influenza vaccines. I...

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Veröffentlicht in:Applied biochemistry and microbiology 2018-09, Vol.54 (5), p.512-517
Hauptverfasser: Markushin, S. G., Akopova, I. I., Blagodatskikh, I. V., Kulikov, S. N., Bezrodnykh, E. A., Muranov, A. V., Yamskov, I. A., Tikhonov, V. E.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylation
Adjuvants
Biochemistry
Biomedical and Life Sciences
Chitosan
Cytotoxicity
Immunogenicity
Immunostimulation
Influenza
Life Sciences
Medical Microbiology
Microbiology
Molecular weight
Toxicity
Vaccines
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Zusammenfassung:The hemostatic and immunostimulating activity and cytotoxicity were determined for a number of chitosans differing in molecular weight (from 3 to 510 kDa) and degree of acetylation (from 1 to 25 mol%) that were used as adjuvants in inactivated poliomyelitic, influenza, and live influenza vaccines. It has been shown that the hemostatic activity of chitosan increased sharply with an increase in its molecular weight. In oligochitosan with a molecular weight of
ISSN:0003-6838
1608-3024
DOI:10.1134/S0003683818050149