Dust Generator for Inhalation Studies with Limited Amounts of Archived Particulate Matter
A novel design for a dry-aerosol generator that efficiently produces a well-dispersed dust suspension using small quantities of a PM 2.5 -enriched powder sample is described. The motivation to develop a highly efficient dry-aerosol particle generator was to facilitate collaborative projects that com...
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Veröffentlicht in: | Aerosol science and technology 2005-02, Vol.39 (2), p.85-91 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | A novel design for a dry-aerosol generator that efficiently produces a well-dispersed dust suspension using small quantities of a PM
2.5
-enriched powder sample is described. The motivation to develop a highly efficient dry-aerosol particle generator was to facilitate collaborative projects that combine in vitro cell culture experiments and multiday inhalation exposures using a single batch of well-characterized particles. Premixing of the test particles with larger diameter glass beads permits delivery of aerosol concentrations from 100-1000 μ g/m
3
to an exposure chamber using only milligram quantities of the test powder per hour. Examination of exposure chamber filter samples by scanning electron microscopy showed well-dispersed particles of the test powder free of glass spheres or fragments. Data are presented from experiments using coal fly ash as the test powder to illustrate the system performance. |
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ISSN: | 0278-6826 1521-7388 |
DOI: | 10.1080/027868290903899 |