PEGylated carbon dot/MnO2 nanohybrid: a new pH/H2O2-driven, turn-on cancer nanotheranostics
The effect of tumor-targeted photodynamic therapy (PDT) was improved by designing nanotheranostics to promote oxygenation in a tumor microenvironment (TME) wherein hypoxia, acidosis, and the elevated levels of H 2 O 2 are three main characteristics. In this study, a carbon dot (CD) PDT agent recentl...
Gespeichert in:
Veröffentlicht in: | Science China materials 2018-10, Vol.61 (10), p.1325-1338 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | The effect of tumor-targeted photodynamic therapy (PDT) was improved by designing nanotheranostics to promote oxygenation in a tumor microenvironment (TME) wherein hypoxia, acidosis, and the elevated levels of H
2
O
2
are three main characteristics. In this study, a carbon dot (CD) PDT agent recently developed by our group was firstly applied as reducing agent to react with potassium permanganate for fabricating CDs/manganese dioxide (CDs/MnO
2
) composites, which were in turn modified with polyethylene glycol (PEG) to form water-soluble CDs/MnO
2
-PEG nanohybrids. In a normal physiological environment, the as-prepared nanohybrids exhibited quenched fluorescence, weak singlet oxygen generation, and low magnetic resonance imaging (MRI) signal. However, given the high sensitivity of MnO
2
to the TME, the CDs/MnO
2
-PEG nanohybrids changed from an “off” to an “on” state with synchronously enhanced fluorescence, singlet oxygen generation, and MRI signal in the TME.
In vitro
and
in vivo
analyses have revealed that CDs/MnO
2
-PEG nanohybrids could be applied as TME-driven, turn-on nanotheranostics for the MR/fluorescence bimodal imaging-guided PDT of cancer. Moreover, complete clearance of CDs/MnO
2
-PEG nanohybrids from the body of mice was observed, indicating their low long-term toxicity and good biocompatibility. This work offers a new nanotheranostic candidate for modulating the unfavorable TME, particularly for the targeted PDT of cancer through precise positioning and oxygen generation. |
---|---|
ISSN: | 2095-8226 2199-4501 |
DOI: | 10.1007/s40843-018-9261-x |