The Effect of Mesenchymal Stem Cell-Derived Microvesicles on Erythroid Differentiation of Umbilical Cord Blood-Derived CD34^sup +^ Cells

Conclusion: The results of this study showed that MSC-MVs decrease the erythroid differentiation of umbilical cord blood-derived CD34+ cells. [...]MSC-MV s play a key role in the regulation of normal erythropoiesis. [...]because of MSCs have the supportive role in hematopoiesis and it is guessed that the MSC-MVs simulate the same effect of MSCs, it is necessary to investigate the effect of MSC-MVs on determining HSC fate. [...]in the present study, we isolated CD34+ cells from umbilical cord blood, as well as, microvesicles from MSCs culture in vitro. [...]we survived the effects of MSCMVs on the erythroid differentiation of UCB-derived CD34+ cells. In current study, we demonstrated that MSC-MVs suppress erythroid differentiation of UCB-derived CD34+ cells. [...]the inhibitory effects of MSC-MVs on normal erythropoiesis should be considered when these vesicles were applied in cell-free therapy.