Cell Surface Hydrophobicity as a Virulence Factor in Candida albicans

Cell surface hydrophobicity (CSH) is one of the important virulence attributes which helps Candida albicans to be a successful fungal pathogen. It influences several steps in pathogenesis of C. albicans leading to establishment of infection. CSH plays an important role in adhesion of cells to host t...

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Veröffentlicht in:Biosciences, biotechnology research Asia biotechnology research Asia, 2017-12, Vol.14 (4), p.1503-1511
Hauptverfasser: R. Goswami, Renuka, D. Pohare, Suhas, S. Raut, Jayant, Mohan Karuppayil, S.
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creator R. Goswami, Renuka
D. Pohare, Suhas
S. Raut, Jayant
Mohan Karuppayil, S.
description Cell surface hydrophobicity (CSH) is one of the important virulence attributes which helps Candida albicans to be a successful fungal pathogen. It influences several steps in pathogenesis of C. albicans leading to establishment of infection. CSH plays an important role in adhesion of cells to host tissues and catheters/medical devices implanted in patients. Adhesion to surfaces and subsequent biofilm formation are crucial because it may result in resistance to antifungal drugs. This important pathogenicity determinant would also be an attractive antifungal target. Various studies indicate that antifungal drugs tend to lower the CSH of Candida cells. Interestingly, molecules of plant origin have been reported to modulate CSH, reduce adhesion and interfere in biofilm formation by C. albicans. The review presents a brief account of biochemical basis of CSH, its role in adhesion and biofilm formation by C. albicans as well as explores it as an antifungal drug target.
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subjects Acids
Adhesion
Biofilms
Candida
Candida albicans
Catheters
Cell surface
Chemotherapy
Drug resistance
Fungicides
HIV
Human immunodeficiency virus
Hydrophobicity
Medical devices
Medical electronics
Medical equipment
Nosocomial infections
Oils & fats
Pathogenesis
Pathogenicity
Plant cells
Polymers
Prostheses
Proteins
Transplants & implants
Virulence
Virulence factors
title Cell Surface Hydrophobicity as a Virulence Factor in Candida albicans
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