In-Vivo Toxicity Assessment of Biologically Synthesized Iron Oxide Nanoparticles in Zebrafish (Danio Rerio)

Nanoparticles are increasingly used for biomedical purposes. In the past decades, much attention has been paid to toxicity assessment of nanoparticles prior to clinical and biological applications. Iron oxide nanoparticles (IONPs) are being introduced into the consumer market significantly. Effects...

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Veröffentlicht in:Biosciences, biotechnology research Asia biotechnology research Asia, 2018-06, Vol.15 (2), p.419-425
Hauptverfasser: Mohiuddin Hafiz, Shazmin, Sameer Kulkarni, Smital, Kapil Thakur, Mansee
Format: Artikel
Sprache:eng
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Zusammenfassung:Nanoparticles are increasingly used for biomedical purposes. In the past decades, much attention has been paid to toxicity assessment of nanoparticles prior to clinical and biological applications. Iron oxide nanoparticles (IONPs) are being introduced into the consumer market significantly. Effects and accumulation patterns of IONPs were studied using zebrafish embryos. Nanoparticles of iron were synthesized by biological reduction of spinach, using 0.1 M Ferric Chloride. These nanoparticles were characterized by SEM-EDS, XRD, FTIR and AAS were found to have the size range of 100 to 250 nm. Fish (n=12/group) were exposed from 8hpf to 7dpf to 1, 5, 10, 50 and 100 mg/L IONPs. The results showed that LC50 was found to be10 mg/L concentration of iron oxide nanoparticles. 50 mg/L and 100 mg/L concentrations showed developmental toxicity in these embryos, causing mortality, and hatching delay. This study is one of the first on developmental toxicity in zebra fish caused by using biologically synthesised iron oxide nanoparticles.
ISSN:0973-1245
2456-2602
DOI:10.13005/bbra/2645