Open Mass Spectrometry Search Algorithm

Open Mass Spectrometry Search Algorithm

Large numbers of MS/MS peptide spectra generated in proteomics experiments require efficient, sensitive and specific algorithms for peptide identification. In the Open Mass Spectrometry Search Algorithm [OMSSA], specificity is calculated by a classic probability score using an explicit model for mat...

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Veröffentlicht in:arXiv.org 2004-06
Hauptverfasser: Geer, Lewis Y, Markey, Sanford P, Kowalak, Jeffrey A, Wagner, Lukas, Xu, Ming, Maynard, Dawn M, Yang, Xiaoyu, Shi, Wenyao, Bryant, Stephen H
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Ions
Mass spectrometry
Model matching
Proteins
Proteomics
Scientific imaging
Search algorithms
Spectra
Spectroscopy
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Zusammenfassung:Large numbers of MS/MS peptide spectra generated in proteomics experiments require efficient, sensitive and specific algorithms for peptide identification. In the Open Mass Spectrometry Search Algorithm [OMSSA], specificity is calculated by a classic probability score using an explicit model for matching experimental spectra to sequences. At default thresholds, OMSSA matches more spectra from a standard protein cocktail than a comparable algorithm. OMSSA is designed to be faster than published algorithms in searching large MS/MS datasets.
ISSN:2331-8422