Abietane diterpenoids from Lycopodium complanatum

Abietane diterpenoids from Lycopodium complanatum

Five new abietane diterpenoids (complanatins A-E, 1–5) have been isolated from the club moss Lycopodium complanatum, along with two known abietane diterpenoids (xanthoperol and sugiol). Their structures were determined by comprehensive analysis of 1D, 2D NMR, CD and HRESIMS data. The cytotoxic effec...

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Veröffentlicht in:Fitoterapia 2018-07, Vol.128, p.135-141
Hauptverfasser: Weng, YanMei, Yu, Xia, Li, Jing, Dong, QiuZhu, Li, FuShuang, Cheng, Fei, Zhang, Yan, Yao, CaiPing, Zou, ZhenXing, Zhou, WenHao, Tan, GuiShan, Xu, KangPing
Format: Artikel
Sprache:eng
Schlagworte:
Abietane diterpenoid
Biotechnology
Chemical compounds
Cytotoxic
Cytotoxicity
Diterpenes
Herbal medicine
Lung cancer
Lycopodiaceae
Lycopodium complanatum
NMR
Nuclear magnetic resonance
Tumor cell lines
Two dimensional analysis
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Zusammenfassung:Five new abietane diterpenoids (complanatins A-E, 1–5) have been isolated from the club moss Lycopodium complanatum, along with two known abietane diterpenoids (xanthoperol and sugiol). Their structures were determined by comprehensive analysis of 1D, 2D NMR, CD and HRESIMS data. The cytotoxic effects of five compounds (1–4, 7) were evaluated in three human lung cancer cell lines (MSTO-211H, NCI-H2052 and NCI-H226). Compounds 3 and 4 exhibited cytotoxic activities against the three cell lines. In addition, a plausible biogenetic pathway of compounds 1–7 was proposed. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2018.05.014