Synthesis of new acridine-9-carboxylic acid derivatives

New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesize...

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Veröffentlicht in:	Russian chemical bulletin 2018-05, Vol.67 (5), p.878-883
Hauptverfasser:	Melyshenkova, V. V., Kuznetsov, D. N., Ruchkina, A. G., Kobrakov, K. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bromination Carboxylic acids Chemical reactions Chemistry Chemistry and Materials Science Chemistry/Food Science Computer simulation Full Articles Inorganic Chemistry Organic Chemistry Pharmacology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesized compounds.
ISSN:	1066-5285 1573-9171
DOI:	10.1007/s11172-018-2152-1