Ammonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Release
Novel magnetite-ammonium bisphosphonate graft ionic copolymer nanocomplexes (MGICs) have been developed for potential drug delivery, magnetic resonance imaging, and hyperthermia applications. The complexes displayed relatively uniform sizes with narrow size distributions upon self-assembly in aqueou...
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| Veröffentlicht in: | Journal of nanomaterials 2018-01, Vol.2018 (2018), p.1-14 |
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| creator | Davis, Richey M. Riffle, Judy S. Mefford, Olin Thompson Bohórquez, Ana C. Jo, Ami Pothayee, Nipon Hu, Nan Pothayee, Nikorn Fellows, Benjamin Zhang, Rui Rinaldi, Carlos |
| description | Novel magnetite-ammonium bisphosphonate graft ionic copolymer nanocomplexes (MGICs) have been developed for potential drug delivery, magnetic resonance imaging, and hyperthermia applications. The complexes displayed relatively uniform sizes with narrow size distributions upon self-assembly in aqueous media, and their sizes were stable under simulated physiological conditions for at least 7 days. The anticancer drugs, cisplatin and carboplatin, were loaded into the complexes, and sustained release of both drugs was observed. The transverse NMR relaxivities (r2s) of the complexes were 244 s−1 (mM Fe)−1 which is fast compared to either the commercial T2-weighted MRI agent Feridex IV® or our previously reported magnetite-block ionomer complexes. Phantom MRI images of the complexes demonstrated excellent negative contrast effects of such complexes. Thus, the bisphosphonate-bearing MGICs could be promising candidates for dual drug delivery and magnetic resonance imaging. Moreover, the bisphosphonate MGICs generate heat under an alternating magnetic field of 30 kA·m−1 at 206 kHz. The temperature of the MGIC dispersion in deionized water increased from 37 to 41°C after exposure to the magnetic field for 10 minutes, corresponding to a specific absorption rate of 77.0 W·g−1. This suggests their potential as hyperthermia treatment agents as well as the possibility of temperature-dependent drug release, making MGICs more versatile in potential drug delivery applications. |
| doi_str_mv | 10.1155/2018/4341580 |
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The complexes displayed relatively uniform sizes with narrow size distributions upon self-assembly in aqueous media, and their sizes were stable under simulated physiological conditions for at least 7 days. The anticancer drugs, cisplatin and carboplatin, were loaded into the complexes, and sustained release of both drugs was observed. The transverse NMR relaxivities (r2s) of the complexes were 244 s−1 (mM Fe)−1 which is fast compared to either the commercial T2-weighted MRI agent Feridex IV® or our previously reported magnetite-block ionomer complexes. Phantom MRI images of the complexes demonstrated excellent negative contrast effects of such complexes. Thus, the bisphosphonate-bearing MGICs could be promising candidates for dual drug delivery and magnetic resonance imaging. Moreover, the bisphosphonate MGICs generate heat under an alternating magnetic field of 30 kA·m−1 at 206 kHz. The temperature of the MGIC dispersion in deionized water increased from 37 to 41°C after exposure to the magnetic field for 10 minutes, corresponding to a specific absorption rate of 77.0 W·g−1. This suggests their potential as hyperthermia treatment agents as well as the possibility of temperature-dependent drug release, making MGICs more versatile in potential drug delivery applications.</description><identifier>ISSN: 1687-4110</identifier><identifier>EISSN: 1687-4129</identifier><identifier>DOI: 10.1155/2018/4341580</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Binding sites ; Biocompatibility ; Bisphosphonates ; Brain cancer ; Cancer therapies ; Chemistry ; Computer simulation ; Contrast agents ; Cytotoxicity ; Deionization ; Drug delivery systems ; Drugs ; Fever ; Graft copolymers ; Hyperthermia ; Image contrast ; Ligands ; Magnetic fields ; Magnetic resonance imaging ; Magnetite ; Medical imaging ; Nanoparticles ; NMR ; Nuclear magnetic resonance ; Platinum ; Polymers ; Self-assembly ; Sustained release ; Temperature dependence ; Tumors</subject><ispartof>Journal of nanomaterials, 2018-01, Vol.2018 (2018), p.1-14</ispartof><rights>Copyright © 2018 Rui Zhang et al.</rights><rights>Copyright © 2018 Rui Zhang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-dba5dc269588e15b3765c88677836a4a60beda889da324748cfed8bd3ac116b3</citedby><cites>FETCH-LOGICAL-c360t-dba5dc269588e15b3765c88677836a4a60beda889da324748cfed8bd3ac116b3</cites><orcidid>0000-0003-4164-2176 ; 0000-0002-6291-6095 ; 0000-0002-1373-2556</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><contributor>Espinosa, Ana</contributor><contributor>Ana Espinosa</contributor><creatorcontrib>Davis, Richey M.</creatorcontrib><creatorcontrib>Riffle, Judy S.</creatorcontrib><creatorcontrib>Mefford, Olin Thompson</creatorcontrib><creatorcontrib>Bohórquez, Ana C.</creatorcontrib><creatorcontrib>Jo, Ami</creatorcontrib><creatorcontrib>Pothayee, Nipon</creatorcontrib><creatorcontrib>Hu, Nan</creatorcontrib><creatorcontrib>Pothayee, Nikorn</creatorcontrib><creatorcontrib>Fellows, Benjamin</creatorcontrib><creatorcontrib>Zhang, Rui</creatorcontrib><creatorcontrib>Rinaldi, Carlos</creatorcontrib><title>Ammonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Release</title><title>Journal of nanomaterials</title><description>Novel magnetite-ammonium bisphosphonate graft ionic copolymer nanocomplexes (MGICs) have been developed for potential drug delivery, magnetic resonance imaging, and hyperthermia applications. The complexes displayed relatively uniform sizes with narrow size distributions upon self-assembly in aqueous media, and their sizes were stable under simulated physiological conditions for at least 7 days. The anticancer drugs, cisplatin and carboplatin, were loaded into the complexes, and sustained release of both drugs was observed. The transverse NMR relaxivities (r2s) of the complexes were 244 s−1 (mM Fe)−1 which is fast compared to either the commercial T2-weighted MRI agent Feridex IV® or our previously reported magnetite-block ionomer complexes. Phantom MRI images of the complexes demonstrated excellent negative contrast effects of such complexes. Thus, the bisphosphonate-bearing MGICs could be promising candidates for dual drug delivery and magnetic resonance imaging. Moreover, the bisphosphonate MGICs generate heat under an alternating magnetic field of 30 kA·m−1 at 206 kHz. The temperature of the MGIC dispersion in deionized water increased from 37 to 41°C after exposure to the magnetic field for 10 minutes, corresponding to a specific absorption rate of 77.0 W·g−1. This suggests their potential as hyperthermia treatment agents as well as the possibility of temperature-dependent drug release, making MGICs more versatile in potential drug delivery applications.</description><subject>Binding sites</subject><subject>Biocompatibility</subject><subject>Bisphosphonates</subject><subject>Brain cancer</subject><subject>Cancer therapies</subject><subject>Chemistry</subject><subject>Computer simulation</subject><subject>Contrast agents</subject><subject>Cytotoxicity</subject><subject>Deionization</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Fever</subject><subject>Graft copolymers</subject><subject>Hyperthermia</subject><subject>Image contrast</subject><subject>Ligands</subject><subject>Magnetic fields</subject><subject>Magnetic resonance imaging</subject><subject>Magnetite</subject><subject>Medical imaging</subject><subject>Nanoparticles</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Platinum</subject><subject>Polymers</subject><subject>Self-assembly</subject><subject>Sustained release</subject><subject>Temperature dependence</subject><subject>Tumors</subject><issn>1687-4110</issn><issn>1687-4129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqF0cFu1DAUBdAIgUQZ2LFGllhCqJ3EibMcOi2t1JYKzT56sV9mXMV2sB3a-aj-Ix5SwZKF5Sfr-FryzbL3jH5hjPPTgjJxWpUV44K-yE5YLZq8YkX78u_M6OvsTQj3lFa85cVJ9rQ2xlk9G_JVh2nvjstCRHLnxoNBryW5gZ3FmIZbsE46M434iIEMzpO7EaK26fLaJgBWoicbP-_IBkf9C_2BgFXkysBO2x150HGfciMmDCO5PEzo4x690fDHbdGkE4izx3yDE1qV5JL3A0eEgG-zVwOMAd8976tse3G-PbvMr79_uzpbX-eyrGnMVQ9cyaJuuRDIeF82NZdC1E0jyhoqqGmPCoRoFZRF1VRCDqhEr0qQjNV9uco-LrGTdz9nDLG7d7O36cWuoC3l6YNT0ir7vCjpXQgeh27y2oA_dIx2xz66Yx_dcx-Jf1r4XlsFD_p_-sOiMRkc4J9mbaq0Ln8DsfuYZA</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Davis, Richey M.</creator><creator>Riffle, Judy S.</creator><creator>Mefford, Olin Thompson</creator><creator>Bohórquez, Ana C.</creator><creator>Jo, Ami</creator><creator>Pothayee, Nipon</creator><creator>Hu, Nan</creator><creator>Pothayee, Nikorn</creator><creator>Fellows, Benjamin</creator><creator>Zhang, Rui</creator><creator>Rinaldi, Carlos</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>L7M</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-4164-2176</orcidid><orcidid>https://orcid.org/0000-0002-6291-6095</orcidid><orcidid>https://orcid.org/0000-0002-1373-2556</orcidid></search><sort><creationdate>20180101</creationdate><title>Ammonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Release</title><author>Davis, Richey M. ; 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The complexes displayed relatively uniform sizes with narrow size distributions upon self-assembly in aqueous media, and their sizes were stable under simulated physiological conditions for at least 7 days. The anticancer drugs, cisplatin and carboplatin, were loaded into the complexes, and sustained release of both drugs was observed. The transverse NMR relaxivities (r2s) of the complexes were 244 s−1 (mM Fe)−1 which is fast compared to either the commercial T2-weighted MRI agent Feridex IV® or our previously reported magnetite-block ionomer complexes. Phantom MRI images of the complexes demonstrated excellent negative contrast effects of such complexes. Thus, the bisphosphonate-bearing MGICs could be promising candidates for dual drug delivery and magnetic resonance imaging. Moreover, the bisphosphonate MGICs generate heat under an alternating magnetic field of 30 kA·m−1 at 206 kHz. The temperature of the MGIC dispersion in deionized water increased from 37 to 41°C after exposure to the magnetic field for 10 minutes, corresponding to a specific absorption rate of 77.0 W·g−1. This suggests their potential as hyperthermia treatment agents as well as the possibility of temperature-dependent drug release, making MGICs more versatile in potential drug delivery applications.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><doi>10.1155/2018/4341580</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-4164-2176</orcidid><orcidid>https://orcid.org/0000-0002-6291-6095</orcidid><orcidid>https://orcid.org/0000-0002-1373-2556</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Binding sites Biocompatibility Bisphosphonates Brain cancer Cancer therapies Chemistry Computer simulation Contrast agents Cytotoxicity Deionization Drug delivery systems Drugs Fever Graft copolymers Hyperthermia Image contrast Ligands Magnetic fields Magnetic resonance imaging Magnetite Medical imaging Nanoparticles NMR Nuclear magnetic resonance Platinum Polymers Self-assembly Sustained release Temperature dependence Tumors |
| title | Ammonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Release |
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