Lumbar spinal ganglia enhancement after Gadolinium chelate administration: a radio-histological correlation

The aim of the present study was to assess the frequency of enhancement of lumbar spinal ganglia after Gadolinium chelate injection in patients without radiculopathy, and to correlate the enhancement with histology. This study is based on the analysis of MR lumbar examinations conducted on 18 patien...

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Veröffentlicht in:Surgical and radiologic anatomy (English ed.) 2002-04, Vol.23 (6), p.415-419
Hauptverfasser: Demondion, X., Leroy, X., Lapègue, F., Drizenko, A., Francke, J.-P., Cotten, A.
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Sprache:eng
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Zusammenfassung:The aim of the present study was to assess the frequency of enhancement of lumbar spinal ganglia after Gadolinium chelate injection in patients without radiculopathy, and to correlate the enhancement with histology. This study is based on the analysis of MR lumbar examinations conducted on 18 patients without radicular symptoms, or previous surgery of the lumbar spine, or disease of the nervous system. The patients were imaged with a 1.5 T unit. Sagittal images were first obtained with a T1-weighted turbo spin-echo. Axial and sagittal images were then obtained with a T1-weighted turbo spin-echo, fat-saturated sequence after Gadolinium intravenous injection from the T12/L1 to the L5/S1 level. All 180 spinal ganglia demonstrated an important and homogeneous enhancement after Gadolinium injection. Four spinal ganglia obtained by dissection from four different fresh cadavers were studied by light microscopy to determine the potential relationship between contrast enhancement and presence and topography of vessels within the spinal ganglia. Vessels were particularly abundant at the peripheral zone of the spinal ganglia. The post-contrast enhancement of the spinal ganglia after Gadolinium administration has to be known and may be explained by the microvasculature pattern.
ISSN:0930-1038
1279-8517
DOI:10.1007/s00276-001-0415-1