Design, synthesis, and biological evaluation of new 1-aryl-4-(β-D-fructopyranos-3-O-yl)methyl-1H-1,2,3-triazole derivatives

New 1-aryl-4-(β-D-fructopyranos-3- O -yl)methyl-1 H -1,2,3-triazole derivatives have been synthesized by a CuAAC reaction and their antibacterial and antifungal activity has been evaluated. Some of the derivatives showed remarkable in vitro antibacterial activity against Staphylococcus aureus , Staphylococcus epidermidis , Pseudomonas aeruginosa , and Klebsiella pneumoniae and moderate antifungal activity . In addition, molecular docking studies of these compounds into the active site of Staphylococcus aureus tyrosyl-tRNA synthetase were performed. The docking study revealed that all compounds have considerable binding energies and good affinity toward the active site of the enzyme.