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SEE ADDITIONAL CONTENT ONLINEEditorial Comment Percutaneous Hemodynamic Assist Devices: Unloading the Left Atrium to Prevent Atrial Remodeling 751 Kalyanam Shivkumar, Peter HannaLeft Main Revascularization With PCI or CABG in Patients With Chronic Kidney Disease: EXCEL Trial 754 Gennaro Giustino, Roxana Mehran, Patrick W. Serruys, Joseph F. Sabik III, Milan Milojevic, Charles A. Simonton, John D. Puskas, David E. Kandzari, Marie-Claude Morice, David P. Taggart, Anthony H. Gershlick, Philippe Généreux, Zixuan Zhang, Thomas McAndrew, Björn Redfors, Michael Ragosta III, Irving L. Kron, Ovidiu Dressler, Martin B. Leon, Stuart J. Pocock, Ori Ben-Yehuda, Arie Pieter Kappetein, Gregg W. Stone The optimal revascularization strategy for patients with obstructive left main coronary artery disease (LMCAD) and chronic kidney disease (CKD) remains unclear. SEE ADDITIONAL CONTENT ONLINEEditorial Comment Red Blood Cells Deserve Attention in Patients With Type 2 Diabetes 781 Gemma VilahurThe Present and Future JACC State-of-the-Art Review Clinical Diagnosis, Imaging, and Genetics of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: JACC State-of-the-Art Review 784 Estelle Gandjbakhch, Alban Redheuil, Françoise Pousset, Philippe Charron, Robert Frank The diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is particularly challenging, due to the absence of specific unique diagnostic criteria, the subjectivity of some diagnostic parameters, its variable expressivity, and incomplete penetrance. Here, the authors critically review popular hypotheses, discuss their clinical implications, and propose 4 key standing questions to help evaluate mechanistic theories.Letters Coronary Vasospasm-Related Sudden Cardiac Arrest in the Community 814 Victor Waldmann, Wulfran Bougouin, Nicole Karam, Kumar Narayanan, Ardalan Sharifzadehgan, Christian Spaulding, Olivier Varenne, Alain Cariou, Xavier Jouven, Eloi Marijon, on behalf of the Paris-Sudden Death Expertise Center (Paris-SDEC) InvestigatorsRight Heart Remodeling in Olympic Athletes During 8 Years of Intensive Exercise Training 815 Vincent L. Aengevaeren, Stefano Caselli, Cataldo Pisicchio, Fernando M. Di Paolo, Maria T.E. Hopman, Antonio Spataro, Thijs M.H. Eijsvogels, Antonio PellicciaRenal Outcomes and the Relative Benefit and Harm of Intensive Treatment of Hypertension 817 Miguel Bigotte Vieira, Rita Magriço, Catarina Viegas Dias, Lia Leitão, João Sérgio NevesAge, Cardiovascular Risk, and Blood