A Palladium‐Catalyzed Domino Procedure for the Synthesis of Unsymmetrical Ureas

A Palladium‐Catalyzed Domino Procedure for the Synthesis of Unsymmetrical Ureas

A palladium‐catalyzed carbonylative procedure for the synthesis of unsymmetrical ureas has been developed. This one‐pot one‐step cascade procedure is consisted by three individual processes: carbonylation, Curtius rearrangement, and nucleophilic addition. A series of unsymmetrical ureas were prepare...

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Veröffentlicht in:Advanced synthesis & catalysis 2018-08, Vol.360 (15), p.2820-2824
Hauptverfasser: Chen, Bo, Peng, Jin‐Bao, Ying, Jun, Qi, Xinxin, Wu, Xiao‐Feng
Format: Artikel
Sprache:eng
Schlagworte:
Amines
Aromatic compounds
Carbonylation
Carbonyls
Cascade reaction
Chemical synthesis
Curtius rearrangement
Iodides
Palladium
Palladium catalyst
Unsymmetrical urea
Ureas
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Zusammenfassung:A palladium‐catalyzed carbonylative procedure for the synthesis of unsymmetrical ureas has been developed. This one‐pot one‐step cascade procedure is consisted by three individual processes: carbonylation, Curtius rearrangement, and nucleophilic addition. A series of unsymmetrical ureas were prepared from easily available aryl iodides and amines in moderate to excellent yields. This procedure provides a convenient and practical approach for unsymmetrical urea synthesis.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201800496