Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3

Graphical abstract Deregulation of G9a in human HCC. G9a was frequently up-regulated in human HCC and implicated in HCC tumorigenesis and metastasis. The frequent up-regulation of G9a in human HCC was attributed to gene copy number gain at 6p21 and loss of miR-1. The oncogenic function of G9a was at...

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Veröffentlicht in:	Journal of hepatology 2017-10, Vol.67 (4), p.758-769
Hauptverfasser:	Wei, Lai, Chiu, David Kung-Chun, Tsang, Felice Ho-Ching, Law, Dicky Cheuk-Ting, Cheng, Carol Lai-Hung, Au, Sandy Leung-Kuen, Lee, Joyce Man-Fong, Wong, Carmen Chak-Lui, Ng, Irene Oi-Lin, Wong, Chun-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animal models Animals Carcinogenesis Carcinogens Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - genetics Cell Line, Tumor Cell proliferation Chromosome 6 Copy number CRISPR Enzymes Epigenesis, Genetic Epigenetics G9a Gastroenterology and Hepatology Gene amplification Gene Dosage Gene expression Gene Knockdown Techniques Gene Knockout Techniques Gene Silencing Genes, Tumor Suppressor Hepatocellular carcinoma Histocompatibility Antigens - genetics Histocompatibility Antigens - metabolism Histone methyltransferase Histone modifications Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Humans Liver cancer Liver Neoplasms - enzymology Liver Neoplasms - etiology Liver Neoplasms - genetics Liver Neoplasms, Experimental - enzymology Liver Neoplasms, Experimental - etiology Liver Neoplasms, Experimental - genetics Metastases Mice Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism miR-1 Post-transcription RARRES3 Receptors, Retinoic Acid - antagonists & inhibitors Receptors, Retinoic Acid - genetics Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism RNA-mediated interference Tumor suppressor genes Up-Regulation
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Zusammenfassung:	Graphical abstract Deregulation of G9a in human HCC. G9a was frequently up-regulated in human HCC and implicated in HCC tumorigenesis and metastasis. The frequent up-regulation of G9a in human HCC was attributed to gene copy number gain at 6p21 and loss of miR-1. The oncogenic function of G9a was at least partially attributed to the epigenetic silencing of tumor suppressor RARRES3.
ISSN:	0168-8278 1600-0641
DOI:	10.1016/j.jhep.2017.05.015