Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling

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Veröffentlicht in:	Journal of hepatology 2017-10, Vol.67 (4), p.780-790
Hauptverfasser:	Teratani, Toshiaki, Tomita, Kengo, Suzuki, Takahiro, Furuhashi, Hirotaka, Irie, Rie, Hida, Shigeaki, Okada, Yoshikiyo, Kurihara, Chie, Ebinuma, Hirotoshi, Nakamoto, Nobuhiro, Saito, Hidetsugu, Hibi, Toshifumi, Miura, Soichiro, Hokari, Ryota, Kanai, Takanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - toxicity Analgesics Animals Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Cholesterol Cholesterol - metabolism Diet Diet, High-Fat - adverse effects Endocytosis Endosome Endosomes Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Free cholesterol Gastroenterology and Hepatology Hepatocytes Hepatotoxicity Inflammasome Inflammasomes Inflammasomes - drug effects Inflammasomes - metabolism Liver Liver - drug effects Liver - metabolism Liver diseases Liver injury Liver sinusoidal endothelial cell Lysosome Lysosomes Lysosomes - metabolism Male Membrane trafficking Metabolic syndrome Mice Mice, Inbred C57BL Mice, Knockout Obesity Oligodeoxyribonucleotides - pharmacology Protein Transport Protein turnover Proteins rab GTP-Binding Proteins - metabolism Rab7 Signal Transduction TLR9 protein Toll-like receptor 9 Toll-Like Receptor 9 - deficiency Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism Toll-like receptors
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Zusammenfassung:	Graphical abstract
ISSN:	0168-8278 1600-0641
DOI:	10.1016/j.jhep.2017.05.020