F(ab')2 Fragments to Overcome Daratumumab Interference in Transfusion Tests: Letter

F(ab')2 Fragments to Overcome Daratumumab Interference in Transfusion Tests: Letter

Daratumumab is an effective agent in multiple myeloma. Its binding of CD38 on red cells causes false positive results on Coombs' blood-compatibility testing. F(ab')2 fragments of daratumumab block this binding and restore the accuracy of the test.

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Bibliographische Detailangaben
Veröffentlicht in:The New England journal of medicine 2018-07, Vol.379 (1), p.90
Hauptverfasser: Selleng, Kathleen, Gebicka, Patrycja D, Thiele, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
CD38 antigen
Disclosure
Immunoglobulins
Methods
Multiple myeloma
Patients
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Beschreibung
Zusammenfassung:Daratumumab is an effective agent in multiple myeloma. Its binding of CD38 on red cells causes false positive results on Coombs' blood-compatibility testing. F(ab')2 fragments of daratumumab block this binding and restore the accuracy of the test.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc1804751