Map of thorough QT studies with QTc and J-Tpeakc biomarkers

Map of thorough QT studies with QTc and J-Tpeakc biomarkers

Introduction: Recent studies have shown that J-TpeakC can differentiate predominant hERG potassium channel blockers with high Torsade risk from multi-channel blockers (hERG plus late sodium or calcium current block) with low Torsade risk. In this study, we have analyzed ECG effects caused by multipl...

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Veröffentlicht in:Journal of electrocardiology 2017-11, Vol.50 (6), p.859-860
Hauptverfasser: Hosseini, Meisam, Johannesen, Lars, McAfee, Dustin C., Stockbridge, Norman, Strauss, David G., Vicente, Jose, Wong, Alexander
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Sprache:eng
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Biomarkers
Electrocardiography
Potassium
Side effects
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container_end_page 860
container_issue 6
container_start_page 859
container_title Journal of electrocardiology
container_volume 50
creator Hosseini, Meisam
Johannesen, Lars
McAfee, Dustin C.
Stockbridge, Norman
Strauss, David G.
Vicente, Jose
Wong, Alexander
description Introduction: Recent studies have shown that J-TpeakC can differentiate predominant hERG potassium channel blockers with high Torsade risk from multi-channel blockers (hERG plus late sodium or calcium current block) with low Torsade risk. In this study, we have analyzed ECG effects caused by multiple drugs from thorough QT (TQT) studies to explore QTc and J-TpeakC as indicators of predominant hERG versus multi-channel blockers.
doi_str_mv 10.1016/j.jelectrocard.2017.08.046
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source ScienceDirect Journals (5 years ago - present)
subjects Biomarkers
Electrocardiography
Potassium
Side effects
title Map of thorough QT studies with QTc and J-Tpeakc biomarkers
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