Map of thorough QT studies with QTc and J-Tpeakc biomarkers

Map of thorough QT studies with QTc and J-Tpeakc biomarkers

Introduction: Recent studies have shown that J-TpeakC can differentiate predominant hERG potassium channel blockers with high Torsade risk from multi-channel blockers (hERG plus late sodium or calcium current block) with low Torsade risk. In this study, we have analyzed ECG effects caused by multipl...

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Veröffentlicht in:Journal of electrocardiology 2017-11, Vol.50 (6), p.859-860
Hauptverfasser: Hosseini, Meisam, Johannesen, Lars, McAfee, Dustin C., Stockbridge, Norman, Strauss, David G., Vicente, Jose, Wong, Alexander
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Electrocardiography
Potassium
Side effects
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Zusammenfassung:Introduction: Recent studies have shown that J-TpeakC can differentiate predominant hERG potassium channel blockers with high Torsade risk from multi-channel blockers (hERG plus late sodium or calcium current block) with low Torsade risk. In this study, we have analyzed ECG effects caused by multiple drugs from thorough QT (TQT) studies to explore QTc and J-TpeakC as indicators of predominant hERG versus multi-channel blockers.
ISSN:0022-0736
1532-8430
DOI:10.1016/j.jelectrocard.2017.08.046