Induction of the Lung Myofibroblast PDGF Receptor System by Urban Ambient Particles from Mexico City

Platelet-derived growth factor (PDGF) and its receptor system regulate mesenchymal cell proliferation. We recently reported that emission-source fly-ash particles and asbestos fibers induce the PDGF alpha-receptor through a macrophage-dependent pathway, and upregulation of this receptor greatly enha...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 1998-10, Vol.19 (4), p.672-680
Hauptverfasser:	Bonner, James C, Rice, Annette B, Lindroos, Pamela M, O'Brien, Patricia O, Dreher, Kevin L, Rosas, Irma, Alfaro-Moreno, Ernesto, Osornio-Vargas, Alvaro R
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants - immunology Air Pollutants - pharmacology Animals Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Cities Culture Media, Conditioned - pharmacology Endotoxins - immunology Fibroblasts - drug effects Fibroblasts - immunology Fibroblasts - metabolism Interleukin-1 - immunology Interleukin-1 - metabolism Lung - chemistry Lung - immunology Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Male Mexico Rats Rats, Sprague-Dawley Receptors, Platelet-Derived Growth Factor - analysis Receptors, Platelet-Derived Growth Factor - immunology Up-Regulation - immunology Vanadium Compounds - immunology Vanadium Compounds - pharmacology Volcanic Eruptions
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Zusammenfassung:	Platelet-derived growth factor (PDGF) and its receptor system regulate mesenchymal cell proliferation. We recently reported that emission-source fly-ash particles and asbestos fibers induce the PDGF alpha-receptor through a macrophage-dependent pathway, and upregulation of this receptor greatly enhances the mitogenic response of lung myofibroblasts to PDGF (Lindroos and colleagues, Am. J. Respir. Cell Mol. Biol. 1997;16:283-292). In the present study we investigated the effect of particulate matter
ISSN:	1044-1549 1535-4989
DOI:	10.1165/ajrcmb.19.4.3176