Synthesis, photophysical, antibacterial and larvicidal studies on triazolophanes with 5-nitro isophthalate functionality at the intraannular position

1 : 1 and 2 : 2 oligomeric triazolophanes with 5-nitro isophthalate and triazolyl functionalities at the intraannular position have been synthesized by copper( i ) catalyzed 1,3 dipolar cycloaddition of the corresponding propargylic esters with various phenyl substituted aliphatic azides under mild conditions through click methodology. The 1 : 1 oligomeric triazolophanes exhibit good target binding ability and better antibacterial activity against Staphylococcus aureus , Bacillus subtilis , Salmonella typhi and Escherichia coli bacteria than the 2 : 2 oligomeric triazolophanes, supported by molecular docking studies, and triazolophanes T 3 , T 4 and T 5 show good larvicidal activity.