The synthesis of imidazoles and evaluation of their antioxidant and antifungal activities

Tri- and tetra-substituted imidazole compounds were synthesized through in situ oxidation–condensation in the presence of catalytic amount of H 2 PW 12 O 40 ¯ loaded on the ionic liquid-functionalized magnetic nanoparticles. Then, the antioxidant and antifungal activities of the new imidazoles were...

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Veröffentlicht in:	Monatshefte für Chemie 2018-08, Vol.149 (8), p.1447-1452
Hauptverfasser:	Ghorbani-Vaghei, Ramin, Izadkhah, Vida, Mahmoodi, Jafar, Karamian, Roya, Ahmadi Khoei, Masoumeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Antioxidants Ascorbic acid Catalysis Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Condensates Fungicides Fusarium oxysporum Imidazole Inorganic Chemistry Ionic liquids Organic Chemistry Original Paper Oxidation Physical Chemistry Theoretical and Computational Chemistry
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Beschreibung
Zusammenfassung:	Tri- and tetra-substituted imidazole compounds were synthesized through in situ oxidation–condensation in the presence of catalytic amount of H 2 PW 12 O 40 ¯ loaded on the ionic liquid-functionalized magnetic nanoparticles. Then, the antioxidant and antifungal activities of the new imidazoles were evaluated. The effectiveness of the samples as DPPH radical scavengers was confirmed by the measured IC 50 values and thiophenyl-containing product showed the best IC 50 of 0.12 when compared to the standard ascorbic acid. Moreover, all compounds have antifungal activity against Fusarium oxysporum . Graphical Abstract .
ISSN:	0026-9247 1434-4475
DOI:	10.1007/s00706-018-2167-1